TRANCE MIX V

neuroticthought:

skunkbear:

As Virginia Hughes noted in a recent piece for National Geographic’s Phenomena blog, the most common depiction of a synapse (that communicating junction between two neurons) is pretty simple:

Signal molecules leave one neuron from that bulby thing, float across a gap, and are picked up by receptors on the other neuron. In this way, information is transmitted from cell to cell … and thinking is possible.

But thanks to a bunch of German scientists - we now have a much more complete and accurate picture. They’ve created the first scientifically accurate 3D model of a synaptic bouton (that bulby bit) complete with every protein and cytoskeletal element.

This effort has been made possible only by a collaboration of specialists in electron microscopy, super-resolution light microscopy (STED), mass spectrometry, and quantitative biochemistry.

says the press release. The model reveals a whole world of neuroscience waiting to be explored. Exciting stuff!

You can access the full video of their 3D model here.

Credit: Benjamin G. Wilhelm, Sunit Mandad, Sven Truckenbrodt, Katharina Kröhnert, Christina Schäfer, Burkhard Rammner, Seong Joo Koo, Gala A. Claßen, Michael Krauss, Volker Haucke, Henning Urlaub, Silvio O. Rizzoli

In case you all missed it.

fuckyeahhistorycrushes:

Alexander “Sasha” Shulgin, maverick chemist, psychedelic pioneer, and inspiring human being, died 3 days ago at 88 years old. Sasha is best known for popularizing MDMA (Ecstasy) and introducing it to the psychological community, and synthesizing hundreds of new psychoactive chemicals that he first tested on himself.

fuckyeahhistorycrushes:

Alexander “Sasha” Shulgin, maverick chemist, psychedelic pioneer, and inspiring human being, died 3 days ago at 88 years old. Sasha is best known for popularizing MDMA (Ecstasy) and introducing it to the psychological community, and synthesizing hundreds of new psychoactive chemicals that he first tested on himself.

maryrobinette:

gehayi:

youmightbeamisogynist:

naamahdarling:

mythosidhe:

Although I have to point out that there was a piece of speculative science fiction called The Blazing World published by one Margaret Cavendish, Duchess of Newcastle-upon-Tyne in 1666, slightly predating Mary Shelley.

This is the thing. Women have been doing awesome shit since there was awesome shit to do, we’ve BEEN THERE, if anyone bothered to look.

Oh, they looked. And then maliciously and willfully erased us from the books to keep anyone else from “getting ideas.”

Hell, the first named author in history? Enheduanna, a Sumerian high priestess, poet and lyricist. She’s known as the Shakespeare of Sumerian literature.

The first American mystery novel was written by Metta Victoria Fuller Victor, as well as the first dime novel, and the first crime novel..

maryrobinette:

gehayi:

youmightbeamisogynist:

naamahdarling:

mythosidhe:

Although I have to point out that there was a piece of speculative science fiction called The Blazing World published by one Margaret Cavendish, Duchess of Newcastle-upon-Tyne in 1666, slightly predating Mary Shelley.

This is the thing. Women have been doing awesome shit since there was awesome shit to do, we’ve BEEN THERE, if anyone bothered to look.

Oh, they looked. And then maliciously and willfully erased us from the books to keep anyone else from “getting ideas.”

Hell, the first named author in history? Enheduanna, a Sumerian high priestess, poet and lyricist. She’s known as the Shakespeare of Sumerian literature.

The first American mystery novel was written by Metta Victoria Fuller Victor, as well as the first dime novel, and the first crime novel..

(Source: dovsherman, via a-black-car-pulled-up-and)

Tags: books history

phil-anselno:

fuckyou-likethe-devil:

The hardest man in the restaurant business and he uplifts kids

KING

(Source: gordonramsaygifs, via foodopia)

(Source: liyanw, via jews)

Tags: photography

(Source: whatisajanis, via iago-rotten)

my-ear-trumpet:

gwydionmisha:

In my opinion still the best track on one of the best albums ever recorded.

Shriekback - Nemesis

And in the opinion of Nathan Kotecki:

My equivocally favorite contemporary literary critic is Harold Bloom. (I say equivocally because Mr. Bloom occasionally cannot resist his urge to be an onanistic know-it-all.) In his life-changing (for me) book The Western Canon he develops the compelling concept of strangeness as a primary consideration to the canonicity, or primacy, of a work of literature. In an oversimplified nutshell, a great work possesses a nature that either assimilates us (changes what we understand to be the very nature of that artform) or forces us to encounter it on its own terms, forever holding us at an intrigued distance. I think in many ways this concept applies as well to the modern music canon as it does to the great works of literature.

How quintessentially strange (and therefore great) is Shriekback’s ‘Nemesis’, then? I marvel at how fiercely it holds its own, forcing us to reconsider what a great song is capable of being and doing.

After a single beat introduction, ‘Nemesis’ just crashes into existence, full throttle. It’s rock, though there is something resembling a funky scratch disco guitar in there. The song bangs in an industrial fashion, but it’s generally more organic than what we commonly consider industrial. There’s plenty of synthesizer, but not in a particularly new wave form. It’s not quite goth, though it’s gotten plenty of play with the goths, and there is the subject matter…

talesfromthemek:

thestarlighthotel:

Dotwork sleeves, chest, and back | Nazareno Tubaro

I know I’ve posted some photos of this before, but it’s too freaking gorgeous to not post again.

Ugh. Finally found ink for “Poison in the Well” Arthur. This has been giving me massive amounts of writers block. >_

(via menwearingwonderfulthings)

gdfalksen:

John Steed and Emma Peel in The Avengers.

gdfalksen:

John Steed and Emma Peel in The Avengers.

(Source: moonlight-driive)

ORGAN MIX by pugna_vel_intereo.

gdfalksen:

Juha Arvid Helmine: Invisible Empire 

(via madmothmiko)